Effects of Ramadan Fasting on Lipid Profile in Patients with Elevated Cholesterol Levels: A Systematic Review
DOI:
https://doi.org/10.63320/jrhs.v1.i1.9Keywords:
physiological, metabolic changes, beneficial effect, lipid profile, hypercholesterolemiaAbstract
Background: Ramadan fasting involves abstaining from food and drink from dawn until sunset and is practiced by millions of Muslims globally. It causes physiological and metabolic changes, including shifts in lipid metabolism. This review systematically evaluates the effect of Ramadan fasting on lipid profiles in individuals with elevated cholesterol levels.
Methods: A systematic search was conducted in PubMed, Scopus, and Web of Science for studies published between 2000 and 2025. Inclusion criteria involved original studies assessing total cholesterol (TC), LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), and triglycerides (TG) before and after Ramadan fasting in patients with elevated cholesterol. Data were synthesized qualitatively.
Results: Out of 75 screened studies, 30 met inclusion criteria. Most reported significant reductions in TC and TG levels after Ramadan fasting. LDL-C decreased in some studies but remained unchanged in others. HDL-C was generally stable or slightly increased. The most pronounced improvements were observed in patients with higher baseline cholesterol.
Conclusion: Ramadan fasting has a beneficial effect on lipid profiles, especially in reducing TC and TG in hypercholesterolemic individuals. However, changes in LDL-C and HDL-C vary. More controlled studies are needed to clarify mechanisms and long-term outcomes.
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References
Adlouni, A., Ghalim, N., Benslimane, A., et al. (1997). Fasting during Ramadan induces a marked increase in HDL cholesterol and decrease in LDL cholesterol. Annals of Nutrition and Metabolism, 41(4), 242–249.
Afifi, Z. (1997). Daily practices, study performance and health during the Ramadan fast. The Journal of the Royal Society for the Promotion of Health, 117(4), 231–235.
Akaberi, A., Golshan, A., Moojdekanloo, M., & Hashemian, M. (2014). Does fasting in Ramadan ameliorate lipid profile? A prospective observational study. Pakistan Journal of Medical Sciences, 30(4), 708–711.
Akhtar, P., Kazmi, A., Sharma, T., & Sharma, A. (2020). Effects of Ramadan fasting on serum lipid profile. Journal of family medicine and primary care, 9(5), 2337–2341. https://doi.org/10.4103/jfmpc.jfmpc_550_19
Ali, M. H., Baqi, H. R., Qadir, S. A., El Bilbeisi, A. H., Hamafarj, K. K., Taleb, M., & El Afifi, A. (2020). Effects of Ramadan fasting on anthropometric measures, blood pressure, and lipid profile among hypertensive patients in the Kurdistan region of Iraq. Journal of Clinical Hypertension, 22(12), 2222–2230.
Al-Hourani, H. M., & Atoum, M. F. (2007). Body composition, nutrient intake and physical activity patterns in young women during Ramadan. Singapore Medical Journal, 48(10), 906–910.
Al-Shafei, A. I. (2014). Ramadan fasting ameliorates oxidative stress and improves glycemic control and lipid profile in diabetic patients. European Journal of Nutrition, 53(7), 1475–1481.
Atkinson, G., & Reilly, T. (1996). Circadian variation in sports performance. Sports Medicine, 21(4), 292–312.
Azizi, F. (2002). Islamic fasting and health. Annals of Nutrition and Metabolism, 46(4), 234–241.
Bakhotmah, B. A. (2011). Influence of Ramadan fasting on anthropometric parameters and some blood biochemical markers among young Saudi female students. Pakistan Journal of Nutrition, 10(3), 264–268.
Bouhlel, E., Salhi, Z., Bouhlel, H., et al. (2006). Effects of Ramadan fasting on lipid peroxidation, serum lipids, lipoproteins, and fasting blood sugar in trained subjects. Saudi Medical Journal, 27(12), 1813–1817.
El Ati, J., Beji, C., & Danguir, J. (2000). Increased fat oxidation during Ramadan fasting in healthy women: An adaptive mechanism for body-weight maintenance. American Journal of Clinical Nutrition, 72(6), 1529–1534.
El-Hajj Fuleihan, G. (2004). Metabolic changes in Ramadan fasting: A comparison between healthy subjects and type 2 diabetic patients. Diabetes Research and Clinical Practice, 66(1), 85–91.
Fedail, S., Al-Rubeaan, K., & Al-Mousa, H. (1982). Fasting and lipoprotein changes in Saudi men. Annals of Nutrition and Metabolism, 26(2), 93–97.
Hallak, M., & Nomani, M. (1988). The effects of fasting during Ramadan on plasma lipid levels. American Journal of Clinical Nutrition, 48(5), 1197–1210.
Ibrahim, W. (2007). The effect of Ramadan fasting on lipid profile and body weight. Saudi Medical Journal, 28(5), 684–689.
Kul, S., Savaş, E., Öztürk, Z. A., & Karadağ, G. (2013). Does Ramadan fasting affect body weight and blood lipids and fasting blood glucose? A meta-analysis. Journal of Nutrition, 143(6), 819–825.
Mirmiran, P., Bahadoran, Z., & Azizi, F. (2019). Intermittent fasting, insulin resistance, and lipid profiles: Effects of Ramadan fasting. Journal of Nutrition, 149(10), 1670–1676.
Norouzy, A., Mohajeri, S. M., Shakeri, S., Yari, F., Sabery, M., Philippou, E., Varasteh, A. R., & Nematy, M. (2012). Effect of Ramadan fasting on glycemic control in patients with Type 2 diabetes. Journal of endocrinological investigation, 35(8), 766–771. https://doi.org/10.3275/
Salim, I., et al. (2013). Effects of Ramadan fasting on lipid profile and glucose in healthy and hyperlipidemic adults. Current Medical Research and Opinion, 29(4), 343–354.
Salti, I., Bénard, E., Detournay, B., Bianchi-Biscay, M., Le Brigand, C., Voinet, C., Jabbar, A., & EPIDIAR study group (2004). A population-based study of diabetes and its characteristics during the fasting month of Ramadan in 13 countries: results of the epidemiology of diabetes and Ramadan 1422/2001 (EPIDIAR) study. Diabetes care, 27(10), 2306–2311. https://doi.org/10.2337/diacare.27.10.2306
Sedaghat, M., Shahsavan, F., Askarizadeh, F., Nematy, M., Heravian, J., Mahmodi, Z., & Rakhshandadi, T. (2016). Effects of Ramadan Fasting on Blood Pressure and Lipid Profile.
Trabelsi, K., El Abed, K., Trepanowski, J. F., Stannard, S. R., Ghlissi, Z., Ghozzi, H., Masmoudi, L., Jammoussi, K., & Hakim, A. (2011). Effects of ramadan fasting on biochemical and anthropometric parameters in physically active men. Asian journal of sports medicine, 2(3), 134–144. https://doi.org/10.5812/asjsm.34775 Ziaee, V., et al. (2006). The impact of Ramadan fasting on metabolic parameters and anthropometric measures in healthy adults. Singapore Medical Journal, 47(5), 409–414.
Trabelsi, K., K. el Abed, S. R. Stannard, K. Jammoussi, K. Zeghal, and A. Hakim. 2012. “Effects of Fed- Versus Fasted-State Aerobic Training During Ramadan on Body Composition and Some Metabolic Parameters in Physically Active Men.” International Journal of Sport Nutrition and Exercise Metabolism 22:11-18.
Zare, M., Ebrahimzadeh, F., & Hossaini, S. (2011). Effects of Ramadan fasting on lipid profile and body composition in healthy adults. Journal of Fasting and Health, 2(1), 41–44.
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